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APP, C-Terminal Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 25524-1-AP

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Con: 50 μg/150 μl

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Tested Applications
Applications:
ELISA, IHC, WB
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Images See all

APP, C-Terminal Antibody WB SH-SY5Y cells 25524-1-AP

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 25524-1-AP( APP, C-Terminal antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours

APP, C-Terminal Antibody IHC human gliomas tissue 25524-1-AP

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 25524-1-AP( APP, C-Terminal antibody at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

APP, C-Terminal Antibody IHC human gliomas tissue 25524-1-AP

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 25524-1-AP( APP, C-Terminal antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human, mouse
Positive WB detected in:
SH-SY5Y cells, 3T3-L1 cells, HeLa cells
Positive IHC detected in:
human gliomas tissue, human brain tissue, human gliomas tissue
Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
APP, C-Terminal fusion protein Ag22408
Full name:
amyloid beta (A4) precursor protein
Calculated molecular weight:
Observed molecular weight:
100 kDa
GenBank accession number:
BC065529
Gene ID (NCBI):
351
Gene symbol
APP
Synonyms
A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta
Background

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).


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