BAG3 Antibody 30 Publications

Rabbit Polyclonal| Catalog number: 10599-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 72 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HEK-293 cells, K-562 cells, mouse brain tissue, DU 145 cells, mouse uterus tissue, mouse placenta tissue, HeLa cells, rat brain tissue

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-associated athanogene 3

Calculated molecular weight:
61 kDa

Observed molecular weight:
74-80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BAG3

Synonyms
BAG 3, BAG3, BIS, CAIR 1, Docking protein CAIR 1
Background

BAG3 (Bcl2-associated athanogene 3) belongs to the BAG protein family, the co-chaperone that binds to Hsc70/Hsp70 through the BAG domain and modulates their activity in polypeptide folding. BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. Through interacting with different molecular partner, BAG3 influences several cell processes, such as apoptosis, autophagy and cell motility. BAG3 protein has been reported to sustain cell survival, resistance to therapy, and/or motility and metastatization in several tumor types, thus being identified as a potential target for anticancer therapies. In addition, defects in BAG3 are the cause of some myopathy. BAG3 normally migrates around 74-80 kD; a slightly different molecular weight or a doublet form can be observed in some cell types and/or following cell exposure to stressors. A synaptosome associated form of 40 kD has recently been described.


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