BAX Fusion Protein

Catalog number: 23931-1-AP
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279.0000

Freight/Packing £00.00

Size: 09µ/gram

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Product Name:
BAX Rabbit Polyclonal antibody

Catalog No:
23931-1-AP

Source:
E. coli-derived, {{ptg:Vector}}

Peptide Sequence:
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({{ptg:AntigenPeptide}} encoded by BC014175)

Activity:
Not tested.

Endotoxin Level:
Please contact the lab for more information.
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Formulation:
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Reconstitution:
Reconstitute at {{ptg:SizeDesc}} sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage (see Stability and Storage for more details).
If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used).
Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution.

Shipping:
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Stability and Storage:
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Storage of Reconstituted Protein:
Short-term storage: Store at 2-8°C for two weeks.
Long-term storage: Aliquot and store at -20°C to -80°C for up to 6 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).


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