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  • KD/KO Validated

BCCIP Polyclonal antibody

BCCIP Polyclonal Antibody for WB, IP, IF, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 16043-1-AP


BCCIP, Protein TOK 1, TOK 1, TOK1

Tested Applications

Positive WB detected inHeLa cells, A549 cells
Positive IP detected inHeLa cells
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16043-1-AP targets BCCIP in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen BCCIP fusion protein Ag8934
Full Name BRCA2 and CDKN1A interacting protein
Calculated Molecular Weight 314 aa, 36 kDa
Observed Molecular Weight 50-58 kDa
GenBank Accession NumberBC009771
Gene Symbol BCCIP
Gene ID (NCBI) 56647
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

BCCIP (or TOK1) is isolated as a BRCA2- and CDKN1A (p21)-interacting protein and is implicated in homologous recombination (HR) pathway and inhibition of DNA replication stress. BCCIP is an evolutionarily conserved nuclear protein with multiple interacting domains. BCCIP deficiency in mice impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly, which are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. BCCIP is essential for maintaining the transactivation activity of wild type p53 suggesting a potential role of BCCIP in cancer etiology.


Product Specific Protocols
WB protocol for BCCIP antibody 16043-1-APDownload protocol
IF protocol for BCCIP antibody 16043-1-APDownload protocol
IP protocol for BCCIP antibody 16043-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Int J Mol Sci

The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells

Authors - Tingting Wu

Int J Mol Sci

Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells

Authors - Junaid Ali Shah


BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells.

Authors - Yi Sui
  • KD Validated

Protein Cell

Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells.

Authors - Jiaming Su

Biochem Biophys Res Commun

BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.

Authors - Fang Wang

Int J Oncol

Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues.

Authors - Liu Xiaoxia X