BCL11A antibody (mAb) (Clone BCL11A/123)
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
ICC, IF, IHC, WB
CloneNo.
BCL11A/123
Cat No : 61231,61232 61231
Synonyms
Validation Data Gallery
Product Information
| Tested Applications |
ICC, IF, IHC, WB
Applications Validated by Active Motif: WB*: 1 – 2 ug/ml dilution *Note: we recommend the addition of 0.05% Tween 20 to all blocking solutions to reduce background. |
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | This BCL11A antibody was raised against a recombinant protein corresponding to amino acids 637-835 of BCL11A-XL (B-cell lymphoma/leukemia 11A extra long form). |
| Full Name | BCL11A antibody (mAb) (Clone BCL11A/123) |
| Synonyms | BCL11A, CTIP1, B-cell CLL lymphoma 11A, COUP-TF-interacting protein 1, is a transcriptional regulator, a myeloid and B-cell proto-oncogene, leukemogenesis, hematopoiesis, hemoglobin gene switching, Mi-2, NuRD chromatin remodeling complex, GATA1, FOG1, erythroid cells, bcl, bcl11, bcl11a, ctip, ctip1, antibody, monoclonal, sample |
| Molecular weight | 100 kDa |
| GenBank accession number | NP_075044 |
| RRID | AB_2793560 |
| Purification Method | Protein G Chromatography |
| Buffer | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
BCL11A (B-cell CLL/lymphoma 11A) is a transcriptional regulator, a myeloid and B-cell proto-oncogene and plays important roles in leukemogenesis and hematopoiesis. BCL11A is involved in regulating hemoglobin gene expression. BCL11A regulates hemoglobin gene switching during fetal development and silencing of g-globin expression in adults. BCL11A interacts with the Mi-2/NuRD chromatin remodeling complexes, as well as the erythroid transcription factors GATA1 and FOG1. Abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells.