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C6orf150 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 26416-1-AP

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Con: 60 μg/150 μl

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Tested Applications

Applications:
WB, IP, IF, ELISA
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Images See all

C6orf150 Antibody WB HL-60 cells 26416-1-AP

HL-60 cells were subjected to SDS PAGE followed by western blot with 26416-1-AP (C6orf150 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours

C6orf150 Antibody WB HL-60 cells 26416-1-AP

Various lysates were subjected to SDS PAGE followed by western blot with 26416-1-AP (C6orf150 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours

C6orf150 Antibody IF HeLa cells 26416-1-AP

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HeLa cells using 26416-1-AP(C6orf150 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human
Positive WB detected in:
HL-60 cells, THP-1 cells
Positive IF detected in:
HeLa cells
Recommended dilution:
WB : 1:1000-1:4000
IF : 1:20-1:200
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
C6orf150 fusion protein Ag23455
Full name:
chromosome 6 open reading frame 150
Calculated molecular weight:
496aa, 54 kDa
Observed molecular weight:
58 kDa
GenBank accession number:
BC113608
Gene ID (NCBI):
115004
Gene symbol
C6orf150
Synonyms
C6orf150, cGAS, Cyclic GMP-AMP synthase, h-cGAS, MB21D1

Background

cGAS (Cyclic GMP-AMP synthase), also known as C6orf150 or h-cGAS, is a 522 aa protein. cGAS mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. The cGAS sensor not only recognizes cytosolic dsDNA but also synthesizes the second messenger cGAMP from ATP and GTP, which then binds to and activates STING. STING undergoes conformational changes and translocation from the endoplasmic reticulum to the Golgi apparatus to encounter TBK1 and IRF3, eventually triggering the production of type I IFNs.


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