CA2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16961-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse ovary tissue, human stomach tissue, rat kidney tissue

Positive IP detected in:
mouse kidney tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
carbonic anhydrase II

Calculated molecular weight:
260aa,29 kDa

Observed molecular weight:
29 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CA2

Synonyms
CA II, CA2, CAC, CAII, Car2, Carbonate dehydratase II, Carbonic anhydrase 2, Carbonic anhydrase C, carbonic anhydrase II
Background

CA2(carbonic anhydrase II ) is also named as Car2, CA-II, CAII and belongs to the alpha-carbonic anhydrase family. It reversibly hydrates CO2 in cellular ion transport and homeostasis. CA2 is essential for bone resorption and osteoclast differentiation. It regulates SLC9A1 activity via a phosphorylation-regulated CAII binding site in SLC9A1 tail(PMID:16475831). It also may be involved in the development of brain(PMID:16825953). Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3).


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