calreticulin Antibody 10 Publications

Rabbit Polyclonal| Catalog number: 10292-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 56 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
NIH/3T3 cells, HeLa cells, HL-60 cells, rat brain tissue, MCF-7 cells, COLO 320 cells, human skeletal muscle tissue, mouse brain tissue

Positive IHC detected in:
human thyroid tissue, human colon cancer tissue, human ovary tumor tissue, human skeletal muscle tissue, human thyroid tissue

Positive IF detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
calreticulin

Calculated molecular weight:
60 kDa

Observed molecular weight:
60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CALR

Synonyms
CALR, Calregulin, calreticulin, cC1qR, CRP55, CRT, CRTC, ERp60, FLJ26680, grp60, HACBP, RO, SSA
Background

CALR,also named as grp60, ERp60, HACBP, CRP55, CRTC and Calregulin, belongs to the calreticulin family. It is a molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. CALR is a ER marker. It interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. CALR interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. The MW of CALR migrates aberrantly at 60 kD by SDS-PAGE. Some study provided that it's a new possibility for CRT-mediated tumor immune prevention and treatment.


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