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Caspase 10 (CASP10) is also called MCH4, is a member of the peptidase C14A family, and contains two death
effector (DED) domains.
What is the molecular weight of CASP10?
The molecular weight of CASP10 observed on Western blots may vary depending on which of its isoform,
truncation, or cleavage forms are present. Full-length CASP10 has a propeptide with 219 amino acid and
6 isoforms produced by alternative splicing.
What is the tissue specificity of CASP10?
CASP10 is detectable in most tissues. However, there is lower expression observed in brain, kidney, colon,
prostate, and testis tissue.
What is the function of CASP10?
CASP10 plays a role in the cascade of caspases responsible for executing apoptosis. It is recruited to both the
Fas and TNFR-1 receptors in a FADD-dependent manner. CASP10 is responsible for the cleavage and activation of
caspases 3, 4, 6, 7, 8, and 9. CASP10 can be cleaved by granzyme B and autocatalytic activity to generate two
active subunits from its inactive proenzyme form.
What is the role of CASP10 in disease?
Defects in CASP10 lead to autoimmune lymphoproliferative syndrome type 2A (ALPS2A), which is characterized
by abnormal lymphocyte and dendritic cell homeostasis, as well as immune regulatory defects (PMID:16446975).
Defects in CASP10 are also a cause of familial non-Hodgkin lymphoma (NHL) and often marked by enlarged lymph
nodes, weight loss and fever (PMID:12010812), and gastric cancers (GASC) (PMID:11973654).