Caspase 10/p23/17/p12 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14311-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, Apoptosised HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human endometrial cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
caspase 10, apoptosis-related cysteine peptidase

Calculated molecular weight:
59 kDa

Observed molecular weight:
59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASP10

Synonyms
ALPS2, Apoptotic protease Mch 4, CASP 10, CASP10, Caspase 10, Caspase 10/p23/17/p12, Caspase10, FLICE2, ICE like apoptotic protease 4, MCH4
Background

CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). The full lengthe has a propeptide with 219 amino acid and 6 isoforms produced by alternative splicing.


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