Caspase 6/p18/p11 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10198-1-AP

Featured Product KD/KO validated

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Con: 44 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, HeLa cells, mouse brain tissue

Positive IHC detected in:
human prostate cancer tissue, human lung cancer tissue, human skin tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
caspase 6, apoptosis-related cysteine peptidase

Calculated molecular weight:
33 kDa,22 kDa

Observed molecular weight:
33-35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

Apoptotic protease Mch 2, CASP 6, CASP6, Caspase 6, Caspase 6/p18/p11, Caspase6, MCH2

Caspase-6 belongs to caspase family of cysteinyl-aspartate specific proteases.Precursor of CASP6 produces two subunits, large (18kDa) and small (16kDa) that dimerize. It cleaves poly(ADP-ribose) polymerase, as well as lamins and is involved in the activation cascade of caspases responsible for apoptosis execution. Researches showed that CASP6 could be an early instigator of neuronal dysfunction and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. IRAK3 is an important target for CASP6. It can reveal five bands of 28, 32, 36, 49, and 64 kDa in human neurons and fetal brain in western blot, the 32 and 28 kDa bands represent procaspase-6 and pro-arm caspase-6. Procaspase-6 is more abundant than pro-arm caspase-6 in adult tissue, whereas pro-arm caspase-6 is more abundant than pro-caspase-6 in fetal brain and cultured neurons. The higher molecular mass bands at 49 and 64 kDa likely represent dimers of p28 and p32.(PMID:10438520). In rat testis, it can be detected two bands of 34 kDa and 12 kDa or 14 kDa(PMID:12538628).

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