CBX8 antibody (pAb)
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB
Cat No : 61237,61238 61237
Synonyms
Validation Data Gallery
Product Information
| Tested Applications |
WB
Applications Validated by Active Motif: WB: 1:500 dilution |
| Tested Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This CBX8 antibody was raised against a peptide corresponding to the C-terminal region of human CBX8 (Chromobox protein homolog 8). |
| Full Name | CBX8 antibody (pAb) |
| Synonyms | CBX8, chromobox homolog 8, PC3, polycomb 3 homolog, RC1, rectachrome 1, Pc class 3 homolog, antibody, polyclonal, sample, transcription regulator, chromatin, histones, h2a, hox, stem cell, stem cells |
| Molecular weight | 45 kDa |
| GenBank accession number | NP_065700 |
| RRID | AB_2793563 |
| Purification Method | Affinity Purified |
| Buffer | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
CBX8 (chromobox homolog 8, PC3, RC1) is a Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.