|Positive IF detected in||HeLa cells|
|Positive FC detected in||HeLa cells|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
65051-1-Ig targets CD107a / LAMP1 in WB, IF, FC applications and shows reactivity with Human samples.
|Cited Reactivity||human, monkey|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human adherent peripheral blood cells|
|Full Name||lysosomal-associated membrane protein 1|
|GenBank accession number||BC006345|
|Gene ID (NCBI)||3916|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at 2-8°C. Stable for one year after shipment.|
LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).