CD320 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10343-1-AP

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human, mouse, cat, dog

Positive WB detected in:
HEK-293 cells, HL-60 cells, human liver tissue, mouse heart tissue, Raji cells

Positive IHC detected in:
human tonsillitis tissue

Positive FC detected in:
HL-60 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD320 molecule

Calculated molecular weight:
29 kDa

Observed molecular weight:
50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD320

Synonyms
8D6, 8D6 antigen, 8D6A, CD320, CD320 antigen, CD320 molecule, FDC signaling molecule 8D6, FDC SM 8D6, TCblR, Transcobalamin receptor
Background

CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29kD. The 58kd size by SDS-PAGE suggests extensive glycosylation of the membrane-anchored protein.


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