CD86 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 13395-1-AP

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
Jurkat cells, Raji cells

Positive IHC detected in:
human tonsillitis tissue

Positive FC detected in:
Raji cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD86 molecule

Calculated molecular weight:
329aa,38 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD86

Synonyms
Activation B7 2 antigen, B7 2, B70, BU63, CD28LG2, CD86, CD86 molecule, FUN 1, LAB72
Background

CD86 (also known as B7.2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. This antibody detects a band of approximately 70 kDa, consistent with glycosylated form of CD86 (PMID: 8592066, 21849678).


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