CNOT1 Antibody 25 Publications

Rabbit Polyclonal| Catalog number: 14276-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, mouse spleen tissue, mouse kidney tissue, HEK293 cells , mouse brain tissue, mouse thymus tissue, mouse heart tissue, HEK-293 cells

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human heart tissue, human spleen tissue, human kidney tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CCR4-NOT transcription complex, subunit 1

Calculated molecular weight:
267 kDa

Observed molecular weight:
240-250 kDa,174 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CNOT1

Synonyms
AD 005, CCR4 associated factor 1, CDC39, CNOT1, DKFZp686E0722, DKFZp686O168, FLJ36492, FLJ90644, hNOT1, KIAA1007, NOT1, NOT1H
Background

CNOT1 is a component of CCR4-NOT protein complex, which is a regulator of RNA polymerase II transcription, acts as a transcription repressor. CCR4-NOT complex could participate in transcription as well as mRNA degradation. It's highly expressed in brain, heart, thymus, but weak in skeletal muscle and colon. CNOT1 undergoes alternative splicing to produce four isoforms.This is a rabbit polyclonal antibody raised against part chain of C-terminal CNOT1 of human origin. CNOT1 exsits as many isoforms and molecular weight of isoforms are 267, 241 and 173 kDa.


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