COX7A2L Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 11416-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse, rat, human; mouse

Positive WB detected in:
mouse brain tissue, mouse brain tissue, rat brain tissue, rat liver tissue

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome c oxidase subunit VIIa polypeptide 2 like

Calculated molecular weight:
114aa,13 kDa

Observed molecular weight:
14 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
COX7A2L

Synonyms
COX7a related protein, COX7A2L, COX7AR, COX7RP, EB1, SIG81
Background

Cytochrome c oxidase (COX) is the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. The mitochondrially encoded subunits function in electron transfer, and the nuclear encoded subunits may function in the regulation and assembly of the complex. COX7A2L (cytochrome c oxidase subunit 7A-related protein), also known as COX7AR or COX7RP, is an inner mitochondrial membrane protein. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. Recently it was found that DNA mythylation of COX7A2L had a significant association with therapy response in patients with breast cancer. In Alzheimer’s disease the expression of COX7A2L was reduced.


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