• Featured Product
  • KD/KO Validated

CPS1 Polyclonal antibody

CPS1 Polyclonal Antibody for IF, IHC, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 18703-1-AP


CPS1, CPSase I

Tested Applications

Positive WB detected inmouse liver tissue, HeLa cells, rat liver tissue
Positive IHC detected inhuman liver cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:2000-1:14000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

18703-1-AP targets CPS1 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name carbamoyl-phosphate synthetase 1, mitochondrial
Calculated Molecular Weight 165 kDa
Observed Molecular Weight140-165 kDa
GenBank Accession NumberBC140943
Gene Symbol CPS1
Gene ID (NCBI) 1373
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CPS1 is an enzyme that catalyzes the first committed step of the hepatic urea cycle, which is important in the removal of excess urea from cells. Expressed primarily in the liver and small intestine, CPS1 can be used as a marker for mitochondria in these tissues. In addition, CPS1 expression appears to be lost in adenocarcinomas of the small intestine. The antibody can recognize two isoforms of this gene around 165 kDa and 116 kDa.


Product Specific Protocols
WB protocol for CPS1 antibody 18703-1-APDownload protocol
IHC protocol for CPS1 antibody 18703-1-APDownload protocol
IF protocol for CPS1 antibody 18703-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cancer Cell

Inhibition of De Novo NAD(+) Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage.

Authors - Krishna S Tummala

Nat Commun

Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes.

Authors - Sung-Jae Cha

Mol Metab

SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.

Authors - Wenxiang Zhang


Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

Authors - Xinghong Guo

J Cell Mol Med

Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells.

Authors - Xi Liu
  • KD Validated

Front Cell Dev Biol

Urea as a By-Product of Ammonia Metabolism Can Be a Potential Serum Biomarker of Hepatocellular Carcinoma.

Authors - Changsen Bai
  • KD Validated