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- KD/KO Validated
CX3CR1 Polyclonal antibody
CX3CR1 Polyclonal Antibody for FC, IHC, IP, WB, ELISA
Host / Isotype
Rabbit / IgG
human and More (2)
WB, IP, IHC, IF, FC, CoIP, Cell treatment, ELISA
Cat no : 13885-1-AP
Validation Data Gallery
|Positive WB detected in||HeLa cells, HL-60 cells, K-562 cells, SH-SY5Y cells, U-937 cells|
|Positive IP detected in||SH-SY5Y cells|
|Positive IHC detected in||human tonsillitis tissue, mouse brain tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive FC detected in||K-562 cells|
|Western Blot (WB)||WB : 1:1000-1:4000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
13885-1-AP targets CX3CR1 in WB, IP, IHC, IF, FC, CoIP, Cell treatment, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CX3CR1 fusion protein Ag4149|
|Full Name||chemokine (C-X3-C motif) receptor 1|
|Calculated molecular weight||40 kDa|
|Observed molecular weight||44-47 kDa|
|GenBank accession number||BC028078|
|Gene ID (NCBI)||1524|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
CX3CR1, also known as GPR13, V28 and fractalkine receptor, belongs to the 7-transmembrane G protein-coupled receptor (GPCR) family. It is expressed on microglia, astrocytes, NK cells, monocytes/macrophages, and a subpopulation of T cells. CX3CR1 is the receptor for fractalkine (CX3CL1) and mediates both its adhesive and migratory functions. It also acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro), and some variations in the gene of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Defects in CX3CR1 are a cause of susceptibility to age-related macular degeneration type 12 (ARMD12).
|Product Specific Protocols|
|WB protocol for CX3CR1 antibody 13885-1-AP||Download protocol|
|IHC protocol for CX3CR1 antibody 13885-1-AP||Download protocol|
|IP protocol for CX3CR1 antibody 13885-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2.
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Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles.
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Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Ryan (Verified Customer) (06-15-2018)