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CXCL10/IP10 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10937-1-AP

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Con: 158 μg/150 μl

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Tested Applications

Applications:
IHC, ELISA
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CXCL10/IP10 Antibody IHC human nasopharyngeal carcinoma tissue 10937-1-AP

Immunohistochemical analysis of paraffin-embedded human nasopharyngeal carcinoma tissue slide using 10937-1-AP (CXCL10/IP10 antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

CXCL10/IP10 Antibody IHC human nasopharyngeal carcinoma tissue 10937-1-AP

Immunohistochemical analysis of paraffin-embedded human nasopharyngeal carcinoma tissue slide using 10937-1-AP (CXCL10/IP10 antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human
Positive IHC detected in:
human nasopharyngeal carcinoma tissue, human ovary tumor tissue, human liver cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
IHC : 1:50-1:500
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
CXCL10/IP10 fusion protein Ag1369
Full name:
chemokine (C-X-C motif) ligand 10
Calculated molecular weight:
11 kDa
Observed molecular weight:
GenBank accession number:
BC010954
Gene ID (NCBI):
3627
Gene symbol
CXCL10
Synonyms
C X C motif chemokine 10, C7, crg 2, CXCL10, Gamma IP10, gIP 10, IFI10, INP10, IP 10, IP10, mob 1, SCYB10, Small inducible cytokine B10

Background

CXCL10 ( also known as IP-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is a 12-kDa protein and constitutes two internal disulfide cross bridges. The predicted signal peptidase cleavage generates a 10-kDa secreted polypeptide with four conserved cysteine residues in the N-terminal. The CXCL10 gene localizes on chromosome 4 at band q21, a locus associated with an acute monocytic/B-lymphocyte lineage leukemia exhibiting translocation of t (4; 11) (q21; q23). CXCL10 mediates leukocyte trafficking, adaptive immunity, inflammation, haematopoiesis and angiogenesis. Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ.


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