CXCL8/IL8 Antibody 4 Publications

Mouse Monoclonal| Catalog number: 60141-2-Ig |CloneNo.: 3D11D5

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Freight/Packing

Con: 150 μg/150 μl

Choose size:

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Species specificity:
human

Positive WB detected in:
ag10552, Recombinant protein

Recommended dilution:
WB : 1:2000-1:20000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 8

Calculated molecular weight:
99aa,11 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL8

Synonyms
C X C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, IL 8, IL8, Inteleukin 8, interleukin 8
Background

Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).


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