Validation Data Gallery
|Positive WB detected in||HepG2 cells, Jurkat cells, mouse liver tissue|
|Positive IHC detected in||human liver tissue, human kidney tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:3000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The immunogen of 26756-1-AP is CXCR3 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CXCR3 fusion protein Ag25056|
|Full Name||chemokine (C-X-C motif) receptor 3|
|Calculated molecular weight||368 aa, 41 kDa|
|Observed molecular weight||70 kDa|
|GenBank accession number||BC034403|
|Gene ID (NCBI)||2833|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
CXCR3 (C-X-C chemokine receptor type 3) is a G-protein-coupled seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells. CXCR3 is activated by three related chemokines (CXCL9, CXCL10, and CXCL11) and plays an important role in effector T-cell and NK cell trafficking. CXCR3 has three isoforms termed as CXCR3-A, CXCR3-B and CXCR3-alt with the calculated molecular mass of 41kDa, 46kDa and 29kDa respectively. The apparent molecular mass of CXCR3 detected by some scientists is 70kDa, but 45kDa by some others. (PMID: 16847335, 15150261, 22885102, 19151743)
J Cell Sci
Gap junction-mediated MiR-200b on osteogenesis and angiogenesis in coculture between MSCs and HUVECs.
Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice.
Front Endocrinol (Lausanne)
Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway.
CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway.
Br J Pharmacol
Phosphodiesterase-4 inhibition attenuates murine ulcerative colitis via interfering with mucosal immunity.
A Novel lncRNA Mediates the Delayed Tooth Eruption of Cleidocranial Dysplasia