DAPP1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14722-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
Hela cells

Recommended dilution:
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dual adaptor of phosphotyrosine and 3-phosphoinositides

Calculated molecular weight:
32 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DAPP1

Synonyms
BAM32, DAPP1, DKFZp667E0716, hDAPP1
Background

DAPP1 was identified as dual adaptor for phosphotyrosine and 3-phosphoinositides, a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by a SH2 and a PH domain at its C-terminus (PMID: 10432293). DAPP1 is also referred to B cell adaptor molecule of 32 kDa (Bam32), and is expressed by B lymphocytes, but not T lymphocytes or nonhematopoietic cells. DAPP1/Bam32 was shown to regulate BCR signaling downstream of phosphatidylinositol 3-kinase (PI3K) (PMID: 10770799). Furthermore, DAPP1/Bam32 may server to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for antigen presentation function (PMID: 20495066).


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