Showing 1- [1] of [1] Publications
Author: | Andrea Pawellek | |
Pubmed ID: | 28884683 | |
Journal: | Elife | |
Title: | Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. | |
Application: | IF | |
Species: | human |
By Product Type
By Research Area
Other
Images See all
DDX46, also named as KIAA0801, is a 1031 amino acid protein, which belongs to the DEAD box helicase family. DDX46 has been shown to be required at the early step of pre-spliceosome assembly. It uses the energy released by the hydrolysis of ATP to rearrange local RNA-RNA or protein-RNA interactions. The nuclear DDX46 acted as a negative regulator of the antiviral innate response by recruiting the m6A‘eraser’ ALKBH5 to induce retention of antiviral innate mRNA in the nucleus.