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  • KD/KO Validated

LGP2 Polyclonal antibody

LGP2 Polyclonal Antibody for IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 11355-1-AP


D11LGP2, D11lgp2e, DHX58, LGP2, Protein D11Lgp2 homolog, RIG I like receptor LGP2, RLR

Tested Applications

Positive WB detected inHEK-293 cells
Positive IP detected inmouse liver tissue
Positive IHC detected inhuman breast cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:200-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

11355-1-AP targets LGP2 in WB, IP, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LGP2 fusion protein Ag1910
Full Name DEXH (Asp-Glu-X-His) box polypeptide 58
Calculated molecular weight 678 aa, 77 kDa
Observed molecular weight 77 kDa
GenBank accession numberBC014949
Gene symbol DHX58
Gene ID (NCBI) 79132
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

DHX58(Probable ATP-dependent RNA helicase DHX58) is also named as D11LGP2E, LGP2 and belongs to the RLR subfamily. DHX58, originally identified as a highly expressed gene in mammary tumors, is another cytoplasmic DEX(D/H)-box helicase that can recognize RNA(PMID: 18411269). It acts as a positive, but not negative, regulator of RIG-I-and MDA5-dependent recognition of RNA virus infection and plays a pivotal role in antiviral responses in vivo(PMID:20080593).


Product Specific Protocols
WB protocol for LGP2 antibody 11355-1-APDownload protocol
IHC protocol for LGP2 antibody 11355-1-APDownload protocol
IP protocol for LGP2 antibody 11355-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Biochem Biophys Res Commun

DExH-Box helicase 58 enhances osteoblast differentiation of osteoblastic cells via Wnt/β-Catenin signaling.

Authors - Lei Zhou
  • KD Validated

Cell Rep

Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation.

Authors - Jessica J Lenoir
  • KO Validated


PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.

Authors - Mikhail I Dobrikov

Biochem Biophys Res Commun

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.

Authors - Akihiko Komuro

J Neurovirol

Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus.

Authors - Furr Samantha R SR

J Biol Chem

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA.

Authors - Xiaojun Li