DKK1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 21112-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human placenta tissue, HeLa cells, K-562 cells, Sp2/0 cells

Positive IHC detected in:
human gliomas tissue, human gliomas tissue, human placenta tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dickkopf homolog 1 (Xenopus laevis)

Calculated molecular weight:
266aa,29 kDa

Observed molecular weight:
30-35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DKK1

Synonyms
Dickkopf 1, Dickkopf related protein 1, DKK 1, DKK1, hDkk 1, SK
Background

DKK1, also named a SK and Dickkopf-1, belongs to the dickkopf family. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. SDS-PAGE and Western blot analysis demonstrated that DKK1 is expressed as a 35-kD doublet protein, which is larger than the deduced molecular mass of 26 kD. Sometime DKK1 is expressed as a 42- to 50-kD secreted protein, with little change observed after glycanase treatment.


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