Product Information
12084-1-AP targets DLX4 in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DLX4 fusion protein Ag2716 Predict reactive species |
| Full Name | distal-less homeobox 4 |
| Calculated Molecular Weight | 240 aa, 26 kDa |
| Observed Molecular Weight | 38 kDa |
| GenBank Accession Number | BC016145 |
| Gene Symbol | DLX4 |
| Gene ID (NCBI) | 1748 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q92988 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Globin genes' expression in the β-globin cluster is restricted to erythroid cells, with five different genes expressed during embryonic (e), fetal (Gγ and Aγ), and adult (δ and β) development [PMID:9461381]. Transcriptional activation of globin genes occurs not only by the binding of transcriptional activator proteins to the promoter of the gene being activated but also by a regulatory element located 6 to 18 kb upstream of the β-globin cluster, the locus control region (LCR)[PMID:8791532]. DXL4, also known as BP1, binds to two silencer DNA sequences upstream of the adult human β-globin gene and to a negative control region upstream of the adult δ-globin gene [PMID:11909945].
