Validation Data Gallery
|Positive WB detected in
|Jurkat cells, HeLa cells, HepG2 cells
|Positive IHC detected in
|human oesophagus tissue, human skin cancer tissue, mouse heart tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in
|mouse heart tissue
|Western Blot (WB)
|WB : 1:500-1:2000
|IHC : 1:500-1:2000
|IF : 1:50-1:500
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
13876-1-AP targets Desmocollin 2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|Host / Isotype
|Rabbit / IgG
|Desmocollin 2 fusion protein Ag4956
|Calculated molecular weight
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Desmocollin 2 (DSC2) is a member of the desmocollin subfamily of the cadherin superfamily. The desmocollins (DSC1-3), along with the desmogleins (DSG1-4), are found primarily in epithelia and cardiac muscle where they constitute the adhesive proteins of the intercellular desmosome junctions and are required for cell adhesion and desmosome formation. Mutations in DSC2 gene are associated with arrhythmogenic right ventricular dysplasia-11.
Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model.
Sci Total Environ
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
Br J Cancer
Mapping of truncated O-glycans in cancers of epithelial and non-epithelial origin.
Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions
Mol Ther Oncolytics
Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Jane (Verified Customer) (02-03-2022)
One specific band was found around 120kDa, however, the signal is weak so need to use lower dilution