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  • KD/KO Validated

DSG2 Polyclonal antibody

DSG2 Polyclonal Antibody for IF, IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 21880-1-AP


ARVC10, ARVD10, Cadherin family member 5, CDHF5, desmoglein 2, DSG2, HDGC

Tested Applications

Positive WB detected inHepG2 cells, HEK-293 cells, HeLa cells, A431 cells, A549 cells
Positive IP detected inHepG2 cells
Positive IHC detected inhuman lung cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inA431 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
Immunohistochemistry (IHC)IHC : 1:500-1:2000
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

The immunogen of 21880-1-AP is DSG2 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DSG2 fusion protein Ag16393
Full Name desmoglein 2
Calculated molecular weight 1118 aa, 122 kDa
Observed molecular weight 145-150 kDa
GenBank accession numberBC099655
Gene symbol DSG2
Gene ID (NCBI) 1829
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG2 is a single-pass transmembrane glycoprotein that is widely expressed in epithelial and non-epithelial tissues, such as the intestine, epidermis, testis, and heart (PMID:21715983). Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10), and genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB).


Product Specific Protocols
WB protocol for DSG2 antibody 21880-1-APDownload protocol
IHC protocol for DSG2 antibody 21880-1-APDownload protocol
IF protocol for DSG2 antibody 21880-1-APDownload protocol
IP protocol for DSG2 antibody 21880-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




O-glycan initiation directs distinct biological pathways and controls epithelial differentiation.

Authors - Ieva Bagdonaite

Mol Biol Cell

Plakophilin 3 and Par3 Facilitate Desmosomes' association with the Apical Junctional Complex.

Authors - Indrajyoti Indra

Food Chem Toxicol

Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice.

Authors - Jianhai Zhang

Microscopy (Oxf)

Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes.

Authors - Shoko Ishikawa


Helicobacter pylori Dwelling on the Apical Surface of Gastrointestinal Epithelium Damages the Mucosal Barrier Through Direct Contact.

Authors - Chen Zhang

Virol Sin

Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia.

Authors - Jing Zhang
  • KD Validated


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Saba (Verified Customer) (09-26-2022)

it is said that this antibody is rabbit, however, unfortunately we observed a significant cross reaction with secondary anti mouse antibody.

  • Applications: Immunofluorescence