PERK Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 24390-1-AP

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells

Positive IHC detected in:
human pancreas tissue, human pancreas tissue, human placenta tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
eukaryotic translation initiation factor 2-alpha kinase 3

Calculated molecular weight:
1116aa,125 kDa

Observed molecular weight:
125 kDa, 140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EIF2AK3

Synonyms
DKFZp781H1925, EIF2AK3, HRI, HsPEK, Pancreatic eIF2 alpha kinase, PEK, PERK, WRS
Background

PERK is also named as PEK, EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3) and belongs to the GCN2 subfamily. It acts potentially as a metabolic sensor in the insulin-secreting beta-cells to modulate the trafficking and quality control of proinsulin in the ER relative to the physiological demands for circulating insulin(PMID:20530744).PERK and EIF2AK4 also have a functional role on regulating translation under non-stressed conditions, apart from their long established roles as stress kinases(PMID: 21638082). The full length protein has a signal peptide and a glycosylation site.


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