ELA2 Polyclonal antibody

ELA2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

IF,ELISA

Conjugate

Unconjugated

Cat no : 17943-1-AP

Synonyms

Bone marrow serine protease, ELA2, ELANE, Elastase 2, elastase 2, neutrophil, GE, HLE, HNE, Human leukocyte elastase, Medullasin, NE, Neutrophil elastase, PMN E, PMN elastase



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

IFSee 1 publications below

Product Information

The immunogen of 17943-1-AP is ELA2 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Cited Reactivitybovine
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ELA2 fusion protein Ag12372
Full Name elastase 2, neutrophil
Calculated molecular weight 267 aa, 29 kDa
GenBank accession numberBC074816
Gene symbol ELA2
Gene ID (NCBI) 1991
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ELA2(Neutrophil elastase) is also named as ELAL, NE, HLE, HNE, PMN-E, SERP1, GE, ELANE and belongs to the peptidase S1 family. It is a 33-kDa enzyme with several isoforms that differ in their extent of glycosylation(PMID:12223222). Human neutrophil elastase (HNE) is a serine protease with potent proteolytic activity (3), which is reported to cause mucin secretion (degranulation)(PMID:12169572). It may contribute to the directed migration of leukocytes into flamed postcapillary venules in addition to contributing to the process of tissue emigration(PMID:9683424). The full length protein has a signal peptide,propeptide and three glycosylation sites.

Publications

SpeciesApplicationTitle
bovineIF

Biol Trace Elem Res

Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.

Authors - Xiechen Zhou

Cell Death Discov

Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.

Authors - Nan Wang