|Positive WB detected in||mouse heart tissue, BxPC-3 cells|
|Positive IF detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10684-1-AP targets ETV4 in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ETV4 fusion protein Ag0984|
|Full Name||ets variant 4|
|Calculated molecular weight||54 kDa|
|Observed molecular weight||61 kDa|
|GenBank accession number||BC007242|
|Gene ID (NCBI)||2118|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ETS translocation variant 4 (ETV4), also named as E1A-F or PEA3, is 484 amino acid protein, which contains one ETS DNA-binding domain and belongs to the ETS family. The calculated molecular weight of ETV4 protein is 54 kDa, but the phosphorylated ETV4 is a 54-61 kDa protein. ETV4 as a transcription activator localizes in the nucleus and binds to the enhancer of the adenovirus E1A gene.
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
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Capicua suppresses colorectal cancer progression via repression of ETV4 expression.
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Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.
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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.