|Positive WB detected in||mouse heart tissue, BxPC-3 cells|
|Positive IF detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10684-1-AP targets ETV4 in WB, IHC, IF applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||chicken, human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ETV4 fusion protein Ag0984|
|Full Name||ets variant 4|
|Calculated molecular weight||54 kDa|
|Observed molecular weight||61 kDa|
|GenBank accession number||BC007242|
|Gene ID (NCBI)||2118|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ETS translocation variant 4 (ETV4), also named as E1A-F or PEA3, is 484 amino acid protein, which contains one ETS DNA-binding domain and belongs to the ETS family. The calculated molecular weight of ETV4 protein is 54 kDa, but the phosphorylated ETV4 is a 54-61 kDa protein. ETV4 as a transcription activator localizes in the nucleus and binds to the enhancer of the adenovirus E1A gene.
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade.
Cell Biol Int
ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.
Cancer Cell Int
Capicua suppresses colorectal cancer progression via repression of ETV4 expression.
The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.