|Positive WB detected in||mouse heart tissue, BxPC-3 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
10684-1-AP targets ETV4 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ETV4 fusion protein Ag0984|
|Full Name||ets variant 4|
|Calculated molecular weight||54 kDa|
|Observed molecular weight||61 kDa|
|GenBank accession number||BC007242|
|Gene ID (NCBI)||2118|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
ETS translocation variant 4 (ETV4), also named as E1A-F or PEA3, is 484 amino acid protein, which contains one ETS DNA-binding domain and belongs to the ETS family. The calculated molecular weight of ETV4 protein is 54 kDa, but the phosphorylated ETV4 is a 54-61 kDa protein. ETV4 as a transcription activator localizes in the nucleus and binds to the enhancer of the adenovirus E1A gene.
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Targeting pan-ETS factors inhibits melanoma progression.
Proc Natl Acad Sci U S A
Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer