F5 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20963-1-AP

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Freight/Packing

Con: 56 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse liver tissue

Positive IHC detected in:
human liver cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
coagulation factor V (proaccelerin, labile factor)

Calculated molecular weight:
252 kDa

Observed molecular weight:
145 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
F5

Synonyms
Activated protein C cofactor, Coagulation factor V, F5, FVL, PCCF, Proaccelerin, labile factor
Background

There are 13 blood coagulation factors found in the blood. There are 13 blood coagulation factors found in the blood. F5 has little or no intrinsic procoagulant activity prior to its activation through limited proteolysis by thrombin or F10a at Arg709, Arg1018 and Arg1545. The resulting F5a molecule is a heterodimer that consists of a 105 kDa heavy chain and a 71/74 kDa light chain that are noncovalently associated in a calcium-dependent manner. The intact procofactor molecule (330 kDa) as well as proteins similar in size to the factor Va light chain (74 kDa) and both light chain precursors (280 and 220 kDa) found in factor Va(IIa) were observed. And factor Xa cleaves the factor Va light chain at Arg1765 into fragments of ~30 and ~48 kDa (residues 1546-1765 and 1766-2196, respectively) in the bovine and human systems.


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