Validation Data Gallery
|Positive WB detected in||HeLa cells, PC-3 cells, Jurkat cells, NIH/3T3 cells, MCF-7 cells|
|Positive IP detected in||HeLa cells|
|Positive IHC detected in||human prostate cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||MCF-7 cells|
|Positive FC detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:1000-1:8000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
10655-1-AP targets FKBP52 in WB, IP, IHC, IF, FC applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||FKBP52 fusion protein Ag1019|
|Full Name||FK506 binding protein 4, 59kDa|
|Calculated molecular weight||59 kDa|
|Observed molecular weight||56-59 kDa|
|GenBank accession number||BC007924|
|Gene ID (NCBI)||2288|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. The protein can associate with the Tau function, and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. In addition, FKBP52 is likely to play a role in growth and development of the male genitalia.
|Product Specific Protocols|
|WB protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IHC protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IF protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IP protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|FC protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|Click here to view our Standard Protocols|
The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate.
Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers.
Biol Trace Elem Res
miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride.
Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders.
Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain.
Mol Ther Oncolytics
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.