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G-CSF Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 17185-1-AP

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Con: 25 μg/150 μl

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Tested Applications

Applications:
IHC, IF, ELISA
Application not tested? Please see our Guarantee


Images See all

G-CSF Antibody IHC human pancreas tissue 17185-1-AP

Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 17185-1-AP( G-CSF Antibody) at dilution of 1:50 (under 10x lens)

G-CSF Antibody IHC human pancreas tissue 17185-1-AP

Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 17185-1-AP( G-CSF Antibody) at dilution of 1:50 (under 40x lens)

G-CSF Antibody IF HeLa cells 17185-1-AP

Immunofluorescent analysis of HeLa cells using 17185-1-AP(G-CSF antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human
Positive IHC detected in:
human pancreas tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
HeLa cells
Recommended dilution:
IHC : 1:20-1:200
IF : 1:10-1:100
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
G-CSF fusion protein Ag10968
Full name:
colony stimulating factor 3 (granulocyte)
Calculated molecular weight:
200aa,22 kDa
Observed molecular weight:
GenBank accession number:
BC033245
Gene ID (NCBI):
1440
Gene symbol
CSF3
Synonyms
C17orf33, CSF3, Filgrastim, G CSF, GCSF, G-CSF, Lenograstim, Pluripoietin

Background

Granulocyte colony-stimulating factor (G-CSF), also referred to as CSF3, is a protective cytokine with anti-inflammatory effects. G-CSF is important in promoting survival of the granulocytic lineage cells and proliferation and migration of neutrophils as well as trophoblast cells. G-CSF acts by binding to its receptor G-CSFR (also called CSF3R), which after binding with G-CSF activates the canonical Janus kinase (Jak)/signal transducer, activator of transcription (STAT)and Ras/Raf/MAP kinase pathways. G-CSF potently stimulates the proliferation and release of peripheral blood progenitor cells into the bloodstream and is therefore used to treat neutropenia after chemotherapy. Furthermore, G-CSF levels are elevated upon intensive exercise leading to increased neutrophil counts, which are predominantly due to delayed neutrophil apoptosis.


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