GA repeat Polyclonal antibody
GA repeat Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
human and More (2)
WB, IHC, IF, Dot Blot, ELISA
Cat no : 24492-1-AP
|Positive ELISA detected in||peptide|
|Enzyme-linked Immunosorbent Assay (ELISA)||ELISA : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
|WB||See 4 publications below|
|IHC||See 3 publications below|
|IF||See 2 publications below|
24492-1-AP targets GA repeat in WB, IHC, IF, Dot Blot, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, Drosophila|
|Host / Isotype||Rabbit / IgG|
|Full Name||GA repeat|
|Gene ID (NCBI)|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
The C9orf72 "GGGGCC" repeat sequence codes five repeat peptide "GA repeat; GAGAGAGAGA", "GP repeat; GPGPGPGPG", "GR repeat; GRGRGRGRG", "AP repeat; APAPAPAPA" and "PR repeat; PRPRPRPRP". It was described previously that aggregated forms of poly-GA and poly-GP proteins do not enter the separation gel (PMID: 26374446). This antibody is used to detect the "GA repeat" sequence. This antibody detects the GAGAGAGAGA peptide with dilution 1:32,000 in Elisa.
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology.
EMBO Mol Med
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
Hum Mol Genet
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
J Cell Sci
SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72.
Hum Mol Genet
Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models.