GCLC Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 12601-1-AP

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Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, HEK-293 cells, Jurkat cells, L02 cells, mouse kidney tissue, mouse lung tissue

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human kidney tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glutamate-cysteine ligase, catalytic subunit

Calculated molecular weight:
637aa,73 kDa

Observed molecular weight:
73 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GCLC

Synonyms
Gamma ECS, GCLC, GCS, GCS heavy chain, GLCL, GLCLC
Background

GCLC (Glutamate--cysteine ligase catalytic subunit) belongs to the glutamate--cysteine ligase type 3 family.It is also named as GLCL, GLCLC.It is the first rate-limiting enzyme in glutathione (GSH) biosynthesis.GCLC) gene may be associated with coronary endothelial vasomotor dysfunction and myocardial infarction (MI) (PMID:12598062). Defects in GCLC are the cause of hemolytic anemia (HAGGSD).


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