|Positive WB detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:3000|
|Sample-dependent, check data in validation data gallery|
66838-1-Ig targets HDAC4 in WB, IF, ELISA applications and shows reactivity with Human, rat, mouse samples.
|Tested Reactivity||Human, rat, mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||HDAC4 fusion protein Ag11345|
|Full Name||histone deacetylase 4|
|Calculated molecular weight||972 aa, 106 kDa|
|Observed molecular weight||140 kDa|
|GenBank accession number||BC039904|
|Gene ID (NCBI)||9759|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
HDAC4, also named as HDACA, belongs to the histone deacetylase family. HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
J Mol Cell Cardiol
Cellular heterogeneity and immune microenvironment revealed by single-cell transcriptome in venous malformation and cavernous venous malformation.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.