HuR Antibody 13 Publications

Rabbit Polyclonal| Catalog number: 11910-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 64 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
HEK-293 cells,RAW264.7 , hESC cells, HL-60 cells, Jurkat cells, A431 cells, HeLa cells, NIH/3T3 cells, K-562 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human ovary tumor tissue, human pancreas tissue, human skin tissue

Positive IF detected in:
MCF-7 cells, Ethacrynic acid treated HepG2 cells

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)

Calculated molecular weight:
326aa,36 kDa

Observed molecular weight:
30-37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ELAVL1

Synonyms
ELAV like protein 1, ELAV1, ELAVL1, Hu antigen R, Hua, HuR, MelG
Background

ELAVL1, also named as HUR, belongs to the RRM elav family. It is involved in 3'-UTR ARE-mediated MYC stabilization. ELAVL1 binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, ELAVL1 binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.


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