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Recombinant Human Complement C6 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg4529

Validation Data Gallery

  • Purity of Recombinant Human Complement C6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Complement C6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human Complement C6 protein Cys22-Ala934 (Accession# P13671) with a rabbit IgG Fc tag at the C-terminus.
GeneID 729
Accession P13671
PredictedSize 128.7 kDa
SDS-PAGE 120-130 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Complement C6 protein is part of the complement system and is a key component of the Membrane Attack Complex (MAC), which acts by forming pores in the plasma membrane of target cells in both natural and adaptive immune responses. The C6 protein plays a cytolytic role in the complement pathway and is involved in the immune response and cytolysis process. Together with other components of the complement cascade, it labels and removes pathogens and damaged cells. C6 proteins have been implicated in a variety of diseases, including meningitis and brucellosis. C6 complement deficiency prevents the development of diet-induced atherosclerosis. Drug development for C6 is currently underway.

References:

1. Karadadas E, et al. Clin Biochem. 2020;81:15-19.                                                      
2. Lin K, et al. Blood Adv. 2020;4(9):2049-2057.