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Recombinant Human CD158G/KIR2DS5 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3719

Validation Data Gallery

  • Purity of Recombinant Human CD158G was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD158G was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human CD158G protein His22-His245 (Accession# Q14953) with a rabbit IgG Fc tag at the C-terminus.
GeneID 3810
Accession Q14953
PredictedSize 51.0 kDa
SDS-PAGE 60-85 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

KIR2DS5, a member of the KIR (killer cell immunoglobulin-like receptor) family, is a cell surface receptor expressed by subpopulations of natural killer (NK) cells and T lymphocytes. KIR2DS5 is an activating receptor that binds to a multimer of DAP12 signaling molecules and transmits activation signals through its short cytoplasmic tail. KIR2DS5 is expressed on NK cells and triggers NK cell functions, including cytotoxicity and cytokine release, upon recognition of certain polymorphisms in HLA-C molecules.

References:

1. Mariella Della Chiesa, et al. (2008). Eur J Immunol. 38(8):2284-9.
2. Noriko K Steiner, et al. (2008). Immunogenetics. 60(11):655-67.
3. Jeroen H Blokhuis, et al. (2017). Immun Inflamm Dis. 5(4):461-468.