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Recombinant Human CXCL5 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2939

Validation Data Gallery

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human CXCL5 protein Ala37-Asn114 (Accession# P42830) with a rabbit IgG Fc tag at the C-terminus.
GeneID 6374
Accession P42830
PredictedSize 34.0 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Chemokines are a class of pro-inflammatory cytokines that can recruit and activate chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine family binding CXCR2 (C-X-C Motif Chemokine Receptor 2), a G-protein coupled receptor. CXCL5 is an inflammatory mediator and a powerful attractant for granulocytic immune cells. CXCL5 is a chemokine that promotes tumor formation by triggering the migration of immune cells to tumors and promotes immmuno-suppressive characteristics of the tumor microenvironment. In addition, CXCL5 can also promote tumor cell metastasis and recruit vascular endothelial cells for angiogenesis.

References:

1. Deng, Jie et al. Frontiers in oncology vol. 12 (2022): 944494. 
2. Kawamura, Mikio et al. European journal of cancer (Oxford, England : 1990) vol. 48,14 (2012): 2244-51.
3. Hu, Binwu et al. Cancer cell international vol. 18 (2018): 68. 
4. Begley, Lesa A et al. Neoplasia (New York, N.Y.) vol. 10,3 (2008): 244-54. 
5. Koltsova, Ekaterina K, and Klaus Ley. Immunity vol. 33,1 (2010): 7-9.