Recombinant Human OX40/TNFRSF4 protein (His tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg1261
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human OX40/TNFRSF4 protein Leu29-Ala214 (Accession# P43489) with a His tag at the C-terminus. |
| GeneID | 7293 |
| Accession | P43489 |
| PredictedSize | 21.1 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors. It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule. CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease.
References:
1. Paterson, D J et al. Molecular immunology vol. 24,12 (1987): 1281-90. 2. Roos, A et al. Journal of leukocyte biology vol. 64,4 (1998): 503-10. 3. Croft, Michael. Annual review of immunology vol. 28 (2010): 57-78. 4. Webb, Gwilym J et al. Clinical reviews in allergy & immunology vol. 50,3 (2016): 312-32.