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IL18, also named as IGIF and IL1F4, belongs to the IL-1 family. It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. The IL18 cytokine increased expression of vascular cell adhesion molecule-1(VCAM1) and the adherence of melanoma cells. IL18 plays a major role in atherosclerotic plaque destabilization leading to acute ischemic syndromes. IL18 negatively regulate NAFLD/NASH progression, as well as multiple aspects of metabolic syndrome via modulation of the gut microbiota. This kit is used to quantify IL18 level in vivo.