IKBKG Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 18474-1-AP

Featured Product KD/KO validated

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Con: 29 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HEK-293 cells, mouse brain tissue

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
HeLa cells, mouse embryo tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Calculated molecular weight:
48 kDa

Observed molecular weight:
48 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IKBKG

Synonyms
AMCBX1, FIP 3, FIP3, Fip3p, I kappa B kinase subunit gamma, IkB kinase subunit gamma, IKBKG, IKK gamma, IKKAP1, IKKG, IP, IP1, IP2, IPD2, NEMO, NF kappa B essential modifier, NF kappa B essential modulator
Background

IKBKG, also named as FIP3, NEMO, IKKAP1 and IKKG, is specifically phosphorylate serine or threonine residues that are followed by a proline residue. IKBKG is regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. IKBKG is a predominant 48-kD protein and an N-terminally truncated protein of 45 kDa produced in smaller amounts and translated from methionine-38.


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