IL-12/IL-23 p40 Recombinant antibody, PBS Only

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  WB analysis of Recombinant protein using 83008-1-RR (same clone as 83008-1-PBS)

  Human IL12B recombinant protein(Eg0431)was subjected to SDS PAGE followed by western blot with 83008-1-RR (IL-12/IL-23 p40 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83008-1-PBS in a different storage buffer formulation.

IL-12/IL-23 p40 Uni-rAb^TM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Cat No. 83008-1-PBS

Clone No.240008F4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Cytometric bead array, Indirect ELISA

Synonyms

IL12B, 240008F4, CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL 12 P40

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Product Information

83008-1-PBS targets IL-12/IL-23 p40 in WB, Cytometric bead array, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: IL-12/IL-23 p40 fusion protein Eg0431
• Full Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
• Calculated Molecular Weight: 328 aa, 37 kDa
• GenBank Accession Number: BC067498
• Gene Symbol: IL12B
• Gene ID (NCBI): 3593
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P29460
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Interleukin (IL)-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).