- Featured Product
- KD/KO Validated
IL-6 Polyclonal Antibody for IHC, ELISA
Cat no : 21865-1-AP
B cell stimulatory factor 2, BSF 2, BSF2, CDF, CTL differentiation factor, HGF, HSF, Hybridoma growth factor, IFN beta 2, IFNB2, IL 6, IL6, IL-6, Interferon beta 2, Interleukin 6
|Positive IHC detected in||human tonsillitis tissue, human spleen tissue, human hepatocirrhosis tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The 21865-1-AP immunogen is Fusion Protein IL-6 protein expressed in E. coli.
|Cited Species||dog, goat, human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||IL-6 fusion protein Ag10565|
|Full Name||interleukin 6 (interferon, beta 2)|
|Calculated molecular weight||212aa,24 kDa|
|Observed molecular weight|
|GenBank accession number||BC015511|
|Gene ID (NCBI)||3569|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20oC. Aliquoting is unnecessary for -20oC storage.|
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
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The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Elizabeth Clawson (12-03-2018)