IRS1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 17509-1-AP

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Con: 45 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
A549 cells, A431 cells, HEK-293 cells, PC-3 cells

Positive IP detected in:
A549 cells

Positive IHC detected in:
human breast cancer tissue, human liver tissue

Positive IF detected in:
A549 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
insulin receptor substrate 1

Calculated molecular weight:
1242aa,132 kDa

Observed molecular weight:
160-185 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

HIRS 1, insulin receptor substrate 1, IRS 1, IRS1

Insulin receptor substrate 1 (IRS1) was the first cloned and characterized member of the IRS family which are involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling. IRS1 is phosphorylated by insulin receptor tyrosine kinase and is involved in various cellular processes including DNA repair fidelity, transcriptional activity, and cell growth can support tumor development and progression. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. IRS1 has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS gel as a band of approximately 160-185 kDa.

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