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KDM2B antibody (mAb) (Clone K2K842-13)

Host / Isotype

Mouse / IgG

Reactivity

Human, Mouse

Applications

WB

CloneNo.

K2K842-13

Activ Motif logo

Cat No : 65699,65700,65999 65699

Synonyms

FBXL10 / KDM2B, FBXL10, KDM2B, lysine (K)-specific demethylase 2B, Lysine demethylase 2B, jumonji domain containing 1A, lysine-specific demethylase 2B, 31455, hdm, kdm, lysine demethylase, histone demethylase, CXXC2, FBXL10, JHDM1B, PCCX2, Fbl10, lysine 36 demethylase, h3k36, lysine 36, lys36, k36, lys 36, demethylase, hmtase, lysine 4 demethylase, lysine 4, h3k4, k4, lysine 4, lys4, lys 4, e3 ubiquitin, e3, ubiquitin, h3k4me3, h3k36me2, k4me3, k36me2, hismethpro

Validation Data Gallery

  • KDM2B antibody (mAb) tested by Western blot. Detection of KDM2B by Western blot analysis. 20 ug of HEK293 nuclear extract was run on SDS-PAGE and probed with 0.5 ug of KDM2B antibody.

    KDM2B antibody (mAb) tested by Western blot. Detection of KDM2B by Western blot analysis. 20 ug of HEK293 nuclear extract was run on SDS-PAGE and probed with 0.5 ug of KDM2B antibody.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 0.5 - 2 ug/ml dilution
Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG
Class Monoclonal
Type Antibody
Immunogen This KDM2B antibody was raised against a peptide containing human lysine-specific demethylase 2B of isoform a.
Full Name KDM2B antibody (mAb) (Clone K2K842-13)
Synonyms FBXL10 / KDM2B, FBXL10, KDM2B, lysine (K)-specific demethylase 2B, Lysine demethylase 2B, jumonji domain containing 1A, lysine-specific demethylase 2B, 31455, hdm, kdm, lysine demethylase, histone demethylase, CXXC2, FBXL10, JHDM1B, PCCX2, Fbl10, lysine 36 demethylase, h3k36, lysine 36, lys36, k36, lys 36, demethylase, hmtase, lysine 4 demethylase, lysine 4, h3k4, k4, lysine 4, lys4, lys 4, e3 ubiquitin, e3, ubiquitin, h3k4me3, h3k36me2, k4me3, k36me2, hismethpro
Molecular weight 100 kDa
GenBank accession numberNP_115979.3
Purification Method Protein A Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

KDM2B (lysine (K)-specific demethylase 2B), also known as FBXL10 (F-box and leucine-rich repeat protein 10) is a histone demethylase that preferentially demethylates trimethylated lysine 4 (K4me3) and dimethylated lysine 36 (K36me2) of histone H3. KDM2B displays weak or no activity for mono- and trimethylated H3K36. KDM2B preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which results in inhibition of cell growth and proliferation. KDM2B may also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.