LAMP3 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12632-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse lung tissue, A375 cells, A549 cells, mouse thymus tissue, rat lung tissue

Positive IP detected in:
A549 cells

Positive IHC detected in:
human lung tissue, human lung tissue, human placenta tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lysosomal-associated membrane protein 3

Calculated molecular weight:
416aa,44 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LAMP3

Synonyms
CD208, DC LAMP, DCLAMP, LAMP, LAMP 3, LAMP3, Protein TSC403, TSC403
Background

LAMP3 (lysosome-associated membrane protein 3), also known as DC-LAMP (DC-lysosome-associated membrane glycoprotein), TSC403 or CD208, is a highly glycosylated lysosomal membrane protein that belongs to the LAMP family. The mature glycoprotein has an apparent molecular mass of 70-90 kDa, which is considerably larger than its predicted mass of 44 kDa (PMID: 9768752). LAMP3 is expressed in lung type II pneumocytes, lymphoid organs and dendritic cells. It might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. LAMP3 mRNA is up-regulated in some human cancers (PMID:9721848). LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer (PMID: 16204031).


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