LHCGR Polyclonal antibody

LHCGR Polyclonal Antibody for IP, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC,ELISA

Conjugate

Unconjugated

Cat no : 19968-1-AP

Synonyms

LCGR, LGR2, LH/CG R, LH/CGR, LHCGR, LHR, LHRHR, LSH R, Luteinizing Hormone Receptor



Tested Applications

Positive WB detected inmouse testis tissue, mouse ovary tissue, multi-cells/tissue
Positive IP detected inmouse testis tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:150-1:600 for WB
Sample-dependent, check data in validation data gallery

Product Information

19968-1-AP targets LHCGR in WB, IP, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name LHCGR
Calculated molecular weight 79 kDa
Observed molecular weight 100 kDa
GenBank accession numberNM_000233
Gene symbol LHCGR
Gene ID (NCBI) 3973
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Lutropin-choriogonadotropic hormone receptor (LHCGR, also known as LHR or LSHR) belongs to the rhodopsin-like family of G protein-coupled receptors (GPCRs) and plays a crucial role in the regulation of gonadal functions by stimulating steroidogenesis in response to luteinizing hormone (LH) or hCG (PMID: 15866423). Mutations in LHCGR gene result in familial male-limited precocious puberty, Leydig cell hypoplasia, and empty follicle syndrome (PMID: 30711030). LHCGR protein consists of 699 amino acids with a calculated molecular weight of 79 kDa. Due to massive glycosylation, the molecular mass of the mature LHCGR is higher (85-100 kDa) than the predicted molecular protein mass of 79 kDa (PMID: 23686864; 15866423; 29075189; 15969756).

Protocols

Product Specific Protocols
WB protocol for LHCGR antibody 19968-1-APDownload protocol
IP protocol for LHCGR antibody 19968-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cell Cycle

β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway.

Authors - Weimin Wu
mouseWB

Int J Nanomedicine

La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

Authors - Lu Yuan
ratWB,IHC

Reprod Toxicol

PMID: 24632129

Authors - Kaori Nozawa
humanWB

Hong Kong Med J

Placental biology of Down syndrome in relation to increased gene dosage.

Authors - O G W Wong
ratWB

Hum Exp Toxicol

Evaluation of carvacrol on pituitary and sexual hormones and their receptors in the testicle of male diabetic rats.

Authors - H Shoorei
humanWB

J Assist Reprod Genet

Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.

Authors - Yu-Ting Wan